Genome Sequences of Acholeplasma laidlawii Strains with Increased Resistance to Tetracycline and Melittin.

Natalia B Baranova,Mohamed Amine Dramchini,Maria N Siniagina,Elena S Medvedeva,Marina N Davydova,Olga A Chernova,Alexey A Mouzykantov,Reshad Akbor Prottoy,Tatyana Y Malygina,Vladislav M Chernov,Eugenia A Boulygina

doi:10.1128/genomea.01446-17

Abstract

ABSTRACTAcholeplasma laidlawii is a well-suited model for studying the molecular basis for adapting mollicutes to environmental conditions. Here, we present the whole-genome sequences of two strains of A. laidlawii with increased resistance to tetracycline and melittin.

Highlights

Acholeplasma laidlawii is a well-suited model for studying the molecular basis for adapting mollicutes to environmental conditions
Mutations in the genes associated with the development of tetracycline resistance in different microorganisms were not found in the genome of A. laidlawii PG8RTet
single nucleotide polymorphisms (SNPs) in genes coding membrane and efflux proteins as well as proteases were found in the genome of A. laidlawii PG8RMel

Summary

Introduction

Acholeplasma laidlawii is a well-suited model for studying the molecular basis for adapting mollicutes to environmental conditions. Mutations in the genes associated with the development of tetracycline resistance in different microorganisms were not found in the genome of A. laidlawii PG8RTet. SNPs in genes coding membrane and efflux proteins as well as proteases were found in the genome of A. laidlawii PG8RMel. It is assumed that these proteins are associated with the development of resistance to antimicrobial peptides in different microorganisms [18].

Results

Conclusion