Abstract
First identified in 1982 as a human pathogen, enterohemorrhagic Escherichia coli of the O157:H7 serotype is a major cause of food-borne acquired human infections. Here, we report the genome sequence of the first known strain of this serotype isolated in the United States.
Highlights
Since the initial report in 1982 that Escherichia coli O157:H7 is associated with severe human disease, the serotype O157:H7 has assumed a position of dominance among enterohemorrhagic E. coli (EHEC) serotypes in North America responsible for global widespread outbreaks of severe gastrointestinal disease [1, 2]
Infections typically present with symptoms of bloody diarrhea coupled with severe abdominal pain [5, 6] but can rapidly progress to life-threatening complications, such as hemolytic uremic syndrome (HUS), hemorrhagic colitis (HC), and central nervous system failure [7,8,9,10,11,12]
Unlike the majority of E. coli O157:H7 recovered from humans in the United States [22,23,24], this isolate is stx1 positive and stx2 negative
Summary
Since the initial report in 1982 that Escherichia coli O157:H7 is associated with severe human disease, the serotype O157:H7 has assumed a position of dominance among enterohemorrhagic E. coli (EHEC) serotypes in North America responsible for global widespread outbreaks of severe gastrointestinal disease [1, 2]. The isolation in 1975 of this E. coli O157:H7 strain, designated 2886-75, from an adult with hemorrhagic colitis (HC) [5, 6] predated the 1982 Oregon and Michigan hamburger-associated E. coli O157:H7 outbreaks [6]. Since 1982, this serogroup has emerged as the dominant cause of EHEC infections in North America.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have