Abstract
The surveillance and correct subtyping of hepatitis C virus strains require available and up-to-date publicly available reference genomes. Here, we present the complete open reading frame sequence of a hepatitis C virus genotype 6 strain of an unknown subtype that was discovered during routine subtyping of patients in the clinic.
Highlights
Hepatitis C virus (HCV) is a worldwide pathogen that belongs to the genus Hepacivirus within the Flaviviridae family
Official genotype 6 references and sequences without subtype assignment according to the International Committee on Taxonomy of Viruses (ICTV) classification from May 2019 [2] and HVH-HCV334 were aligned with MUSCLE v.3.8.1551 [13]; a maximum likelihood phylogenetic tree was created with FastTree v.2.1.5 [14] and visualized in FigTree v.1.4.3
Potentially other NS5A inhibitors, was predicted, by HCV GLUE v.0.1.58 [16], due to the resistance-associated amino acids M28 (99%) and S93 (99%) in the NS5A protein [17, 18]. This new genotype 6 genome sequence is important for accurate characterization of HCV for surveillance and prior to antiviral treatment with nonpangenotypic regimens
Summary
Hepatitis C virus (HCV) is a worldwide pathogen that belongs to the genus Hepacivirus within the Flaviviridae family. Official genotype 6 references and sequences without subtype assignment according to the International Committee on Taxonomy of Viruses (ICTV) classification from May 2019 [2] and HVH-HCV334 were aligned with MUSCLE v.3.8.1551 [13]; a maximum likelihood phylogenetic tree was created with FastTree v.2.1.5 [14] and visualized in FigTree v.1.4.3 (http://tree.bio.ed.ac.uk/software/figtree/).
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