Abstract
Mycoplasma meleagridis is a major cause of disease and economic loss in turkeys. Here, we report the genome sequence of an M. meleagridis field strain, which enlarges the knowledge about this bacterium and helps the identification of possible coding sequences for drug resistance genes and specific antigens.
Highlights
Mycoplasma meleagridis is a major cause of disease and economic loss in turkeys
Two genes were identified as YjeE, which are predicted to have essential role in cell wall biosynthesis; another 16 genes were responsible for membrane transport; 15 genes code for amino acids and derivatives; and 132 genes were responsible for protein metabolism, including two responsible for lipoprotein biosynthesis, which represents important information for future studies regarding possible specific antigens for M. meleagridis diagnostics
Four genes for fluoroquinolone resistance were identified and determined to be active together with one multidrug resistance gene belonging to the multidrug and toxic compound extrusion (MATE) superfamily. Their sequences were subjected to a BLAST search against the previously sequenced genome of an M. meleagridis reference strain [4], and we observed some mismatches in the gyrA and multidrug resistance genes
Summary
Mycoplasma meleagridis is a major cause of disease and economic loss in turkeys. Here, we report the genome sequence of an M. meleagridis field strain, which enlarges the knowledge about this bacterium and helps the identification of possible coding sequences for drug resistance genes and specific antigens. A number of antigens appear to be shared between M. meleagridis and the more important poultry mycoplasmas (Mycoplasma gallisepticum and Mycoplasma synoviae) resulting in cross-reactivity that complicates serological investigations [2]. The M. meleagridis strain used in this study was isolated in 2011 at the Istituto Zooprofilattico Sperimentale delle Venezie, Italy, from a turkey with typical mycoplasma symptoms, including skeletal alterations, by using traditional microbiological methods and denaturing gradient gel electrophoresis-PCR (DGGE-PCR) for confirmation.
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