Abstract
The genome sequence of a simian adenovirus from a cynomolgus macaque, denoted CynAdV-1, is presented here. Phylogenetic analysis supports CynAdV-1 in an independent clade, comprising a new simian adenovirus (SAdV) species. These genome data are critical for understanding the evolution and relationships of primate adenoviruses, including zoonosis and emergent human pathogens.
Highlights
Adenoviruses infect a broad range of vertebrate hosts, including humans and nonhuman primates [1]
Adenoviruses are reported in cross-species zoonotic transmissions, for example, between nonhuman primates and human hosts [3,4,5,6,7]
Cross-species zoonotic transmissions have been reported, with both hosts retaining antigenic profiles of the event [3, 4]. These zoonotic events are important, as genome recombination is documented among human adenoviruses (HAdVs) as a pathway of generating novel human pathogens that cause acute respiratory and epidemic keratoconjunctivitis diseases [21,22,23]; genome recombination with simian adenovirus (SAdV) may be another pathway for the genesis of emergent human pathogens [5]
Summary
Adenoviruses infect a broad range of vertebrate hosts, including humans and nonhuman primates [1]. At least 69 different human adenoviruses (HAdVs) and 25 simian adenoviruses (SAdVs) have been described and grouped into eight human (A to G) and one simian (A) species [1, 2]. Adenoviruses are reported in cross-species zoonotic transmissions, for example, between nonhuman primates and human hosts [3,4,5,6,7].
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