Abstract
ObjectiveThis study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large F2 intercross between Landrace and Korean native pigs.MethodsEighteen FA composition traits were measured in more than 960 F2 progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes.ResultsWe detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (F-value = 97.2 under additive and dominance model, nominal p-value 3.6×10−39) accounted for 16.9% of phenotypic variance. In addition, four more QTLs for C18:1, C18:2, C20:4, and monounsaturated fatty acids on the similar position explained more than 10% of phenotypic variance.ConclusionOur findings of a major QTL for FA composition presented here could provide helpful information to locate causative variants to improve meat quality traits in pigs.
Highlights
Fatty acids (FAs) composition plays a crucial role in pork quality
Two types of native pigs exist in Korea: i) the Jeju native pigs raised on the Jeju Island, and ii) native pigs raised on the Korean Peninsula
The Jeju native pig has unique genetic characteristics that differ from those of the native pig in the Korean Peninsula since it has been isolated from the main Korean Peninsula for more than 1,000 years
Summary
This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large F2 intercross between Landrace and Korean native pigs. Methods: Eighteen FA composition traits were measured in more than 960 F2 progeny. We identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (F-value = 97.2 under additive and dominance model, nominal p-value 3.6×10–39) accounted for 16.9% of phenotypic variance. Four more QTLs for C18:1, C18:2, C20:4, and mono unsaturated fatty acids on the similar position explained more than 10% of phenotypic variance. Conclusion: Our findings of a major QTL for FA composition presented here could provide helpful information to locate causative variants to improve meat quality traits in pigs
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