Abstract
Transcription factors (TFs) have long been recognised as powerful regulators of cell type identity. The underlying mechanisms however have remained largely obscure, despite major advances in the generation of genome-wide binding maps. Moreover, how so-called master regulators can contribute to the functionality of multiple distinct cell types is even less-well understood. Here we have compared global binding patterns for 10 key haematopoietic TFs in both mast cells and blood progenitors, revealing largely cell-type specific binding profiles.
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