Abstract
Background: Methanogens utilize low carbon molecules in anaerobic environments and produce CH4 that serves as a key component in the global carbon cycle in the atmosphere. Genome-scale metabolic modeling is a proficient computational tool for integrative analysis of their cellular and metabolic processes. Thus, genome-scale models of methanogens have gained great importance in environmental and biotechnological applications. Keywords: Genome-scale model, rumen methanogens, global warming, reverse methanogenesis, methane mitigation, methane cycling.
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