Genome interpretation: Clinical correlation is recommended

Michael M Segal

doi:10.1016/j.atg.2015.07.002

Abstract

Genome interpretation: Clinical correlation is recommended

Highlights

In a brain MRI report, the following words often appear: “clinical correlation is recommended”
For brain MRI scans, this clinical correlation is institutionalized as neuroradiology rounds held several times a week by many neurology inpatient services
The core principle of clinical correlation should be that detailed information about the patient's findings, the phenotype, is combined with detailed information in the annotated variant table, the genotype

Summary

Introduction

In a brain MRI report, the following words often appear: “clinical correlation is recommended”. When moving beyond single gene tests and simple panels, more clinical correlation is needed. The core principle of clinical correlation should be that detailed information about the patient's findings, the phenotype, is combined with detailed information in the annotated variant table, the genotype.

Results

Conclusion