Abstract
An industrial microorganism, Streptomyces avermitilis, which is the producer of the anthelmintic agent avermectin, has been constructed as a versatile model host for heterologous expression of genes encoding secondary metabolite biosynthesis. Several kinds of the entire biosynthetic gene clusters for secondary metabolites were successively cloned and introduced into a versatile model host, S. avermitilis. Most S. avermitilis transformants carrying the entire gene cluster produced metabolite(s) caused by the expression of the introduced biosynthetic gene clusters. Productivity of the metabolite(s) in some transformants of the versatile host was higher than that of the original producers.
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