Abstract
The members of the genus Avihepatovirus and related picornaviruses (“Aalivius”) of ducks, turkey and chickens possess identical 2A peptide composition including three functionally unrelated 2A peptides which is a characteristic genome feature of these monophyletic avian picornaviruses. The complete genome of a novel picornavirus provisionally named Orivirus A1 (KM203656) from a cloacal sample of a 4-week-old diarrheic chicken (Gallus gallus domesticus) distantly related to members of genus Avihepatovirus was characterized. The study strain contains a type-II-like IRES, a single 2A protein of unknown function unrelated to the 2A proteins of avihepatoviruses and a long 3′ untranslated region (UTR) with multiple repeated sequence motifs followed by an AUG-rich region. The repeated sequences of the 3′ UTR show significant identity to the “Unit A” sequences of the phylogenetically distant megriviruses. The presence of a novel single 2A and the megrivirus-like “Unit A” motifs suggest multiple recombination events in the evolution of this novel picornavirus.
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