Abstract
The bacterium <i>Neobacillus endophyticus</i> BRMEA1<sup>T</sup>, isolated from the medicinal plant <i>Selaginella involvens</i>, known as its thermotolerant can grow at 50°C. To explore the genetic basis for its heat tolerance response and its potential for producing valuable natural compounds, the genomes of two thermotolerant and four mesophilic strains in the genus <i>Neobacillus</i> were analyzed using a bioinformatic software platform. The whole genome was annotated using RAST SEED and OrthVenn2, with a focus on identifying potential heattolerance- related genes. <i>N. endophyticus</i> BRMEA1<sup>T</sup> was found to possess more stress response genes compared to other mesophilic members of the genus, and it was the only strain that had genes for the synthesis of osmoregulated periplasmic glucans. This study sheds light on the potential value of <i>N. endophyticus</i> BRMEA1<sup>T</sup>, as it reveals the mechanism of heat resistance and the application of secondary metabolites produced by this bacterium through whole-genome sequencing and comparative analysis.
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