Abstract
This paper describes GenoMap, an integrated, parallel/distributed computing software system that aids in large-scale gene linkage mapping studies. This problem requires data from heterogeneous, distributed sources. In addition, the users of the system are researchers spanning a wide range of cultures, and represent a broad range of computing needs. A distributed, heterogeneous solution addresses most of the primary challenges, but presents its own difficulties. The key elements of GenoMap are provided by way of a web-based set of interactive Java applets and applications, as well as a small number of native applications, with automated load-balancing support for sharing computationally intensive tasks among a collection of distributed UNIX workstations. While computationally intensive tasks are supported on the most appropriate systems, users are able to conduct most of their work in familiar MacOS and Windows/PC environments through the use of a Java-enabled web browser. We also describe GenoScape, a C & X-Windows/UNIX native application for robust genotyping of a wide range of electrophoresis gel formats.
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