Abstract
Summary of main observation and conclusionGenkwadane F—I (1—4), four new diterpenes, along with four known ones (5—8), were isolated from the flower buds of D. genkwa. The structures including absolute configurations of 1—4 were determined based on the analysis of NMR and ECD calculations. All compounds were evaluated for their cytotoxicities against MCF‐7 and Hep3B cell lines, among which compounds 3 and 4 showed significant activities. Compound 4 exhibited the most potent activity with IC50 values of 1.33 μM against MCF‐7, and the IC50 values of compound 3 against MCF‐7 and Hep3B were 5.54 μM and 8.73 μM, respectively. Further studies by Hoechst 33258 staining and Annexin V/PI analysis demonstrated that compounds 3 and 4 could induce apoptosis to exhibit anti‐tumor activities.
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