Genito-thyroid index (Neutrophil-to-lymphocyte ratio) and basophils as predictors of left ventricular remodeling after acute myocardial infarction

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Background The neutrophil-to-lymphocyte ratio (NLR) is associated with inflammation. The theory of Endobiogeny is a complex systems theory of physiology that evaluates the relationship between biomarkers and endocrine management of adaptation response. NLR is referred to in this system as the "Genito-thyroid index" (GTI) due to the roles of estrogen and thyroid hormones in immune response. Basophils correlate with worse outcomes in critical illness and are stimulated by ACTH when there is delayed cortisol excretion from the adrenal cortex. These biomarkers are routinely obtained after acute myocardial infarction (AMI), but their relationship to AMI and left ventricular ejection fraction (LVEF) have not been established. Purpose The aim of this study was to assess the relationship between the GTI and %Basophils to LVEF in first time AMI. Methods This prospective study included 52 consecutive patients diagnosed with AMI, admitted to the intensive care unit of our university hospital from April 2017 to November 2017. Percent neutrophils, lymphocytes and basophils were determined on admission (GTI1, Basophil1) and before discharge (GTI2, Basophil2). Diagnostic coronary angiography and percutaneous coronary intervention (PCI) was performed for all patients. All patients underwent transthoracic echocardiography within hospitalization period (LVEF1) and after 6 months (LVEF2) during follow up period. Echocardiography was performed using a Philips machine. LV function was assessed by the measurement of EF using the biplane Simpson’s disc summation method through QLAB ultrasound cardiac analysis on apical two- and four-chamber views. Statistical analyses were performed using the SPSS 20.0 software. Spearman’s rank correlation coefficient was used to examine the relationship between different variables. A p-value <0.05 was considered statistically significant. Results Study population mean age was 63.9 ± 11.6 years. Mean GTI1 was 4.5 ± 2.8 (1.5-2.5). Mean GTI2 was 2.8 ± 1.4. Δ GTI1-2 significantly and positively correlated with Δ LVEF1-2 (r = 0.380, p = 0.019). Mean Basophils1 was 0.3 ± 0.2% (<0.2%). Mean Basophil2 was 0.4 ± 0.3%. Δ Basophil1-2 positively correlated with Δ LVEF 1-2 (r = 0.435, p = 0.015). No significant correlation was found between GTI1 and Δ LVEF1-2 (r = 0.137, p = 0.332), or Basophil1 and Δ LVEF1-2 (r = -0.186, p = 0.196). Conclusion Admission values of GTI and basophils, while both elevated did not correlate with LVEF1-2. However, Δ GTI1-2 and Δ basophils1-2 did. From this we conclude that relative recovery of the systemic response to AMI is more significative than initial response and affects myocardial recovery. Monitoring GTI and basophils is commonly performed and inexpensive. It reflects a role of the endocrine system not before investigated in myocardial recovery post-AMI. It may be useful for identifying patients at risk of poor LVEF post-AMI.