Abstract
Staphylococcus aureus (S.aureus), a Gram-positive organism, is a frequent cause of subclinical mastitis. Geniposide, an iridoid glucoside isolated from the fruits of Gardenia jasminoides, has been reported to exhibit antibacterial and anti-inflammatory properties. The ability of S. aureus internalizing into bovine mammary epithelial cells (bMEC) has been responsible for the establishment of the bovine mastitis. In this study, we evaluated the effect of geniposide on S. aureus internalization into bMEC and investigated the possible mechanism of action. The results revealed that geniposide (25–100 μg/ml) reduced S. aureus internalization by 17%–67% and down-regulated the mRNA expressions of TAP and BNBD5. Furthermore, geniposide inhibited S.aureus-induced NF-κB activation in a dose-dependent manner. In summary, the potential mechanism of geniposide reducing S. aureus internalization may be by inhibiting NF-κB activation.
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