Abstract

Asthma, allergic rhinitis and atopic dermatitis are complex diseases that are caused most likely by an interaction of multiple genes and environmental factors. During the last 2 decades, numerous chromosomal regions and genetic variants in candidate genes were identified that showed linkage or association with atopic phenotypes. The objective of this review is a) to explain the methodology of genetic studies of complex traits, b) to summarize chromosomal regions and polymorphisms in genes that have been related to atopic diseases and c) to outline genetic factors that may render individuals more susceptible to asthma and atopy due to environmental changes.

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