Abstract
PD : Parkinson disease Parkinson disease (PD) is a degenerative disorder of the nervous system. It is characterized by loss of dopamine-producing cells which, in time, develops into motor system dysfunction. A small portion of PD cases are purely genetic. Currently, diagnosis is based on clinical
Highlights
Parkinson disease (PD) is a degenerative disorder of the nervous system
HISTORY OF PARKINSON DISEASE The description of tremors and other symptoms of PD is found in ancient texts.[1,2]
WHAT ARE THE CLINICAL MANIFESTATIONS OF PARKINSON DISEASE? PD is a movement disorder with a slow onset, frequently presenting initially with coordination difficulties
Summary
Parkinson disease (PD) is a degenerative disorder of the nervous system It is characterized by loss of dopamine-producing cells which, in time, develops into motor system dysfunction. Bradykenisia, rigidity, postural instability, and resting tremors are the dominant features of the disease.[9] The time lag between the initial symptoms and diagnosis may be several years.[10]. Atypical PD, known as Parkinson Plus Syndromes, represents 15% of patients presenting with Parkinsonlike symptoms. These syndromes (multiple system atrophy, Lewy body dementia, progressive supranuclear palsy, and corticobasal degeneration) do not respond to dopamine therapy. Diagnosis of Parkinson disease is based on the clinically characteristic signs of bradykinesia, rigidity, and resting tremor. Asymmetric onset of symptoms and a response to levodopa are considered supporting diagnostic features.[16]
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