Abstract
Objective: The infertility is a reproductive health problem that affects nearly 7% of all couples in the human population. It has been estimated that nearly 50% of infertility cases are due to genetic defects. Male infertility may be contributory to 30 - 40 % of infertile couples. Male infertility focuses on genetic factors impairing spermatogenesis and structural abnormalities such as Y chromosome microdeletions. The Y chromosome microdeletions are the most frequent genetic cause of male infertility. In this review article, we will focus on the structural abnormality and related gene functions on infertility.
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