Genetics of Corneal Endothelial Dystrophies: An Asian Perspective

Abstract

Corneal endothelial dystrophies are a group of disorders marked by dysfunction and loss of the corneal endothelial cells. The three primary endothelial dystrophies are congenital hereditary endothelial dystrophy, posterior polymorphous corneal dystrophy, and Fuchs’ endothelial corneal dystrophy. Recent advances in human genetics have led to the discovery of several genes associated with these endothelial dystrophies. In this chapter, we review these corneal endothelial dystrophies with specific emphasis on the molecular genetic studies performed on subjects from Asia.