Genetics of Colorectal Cancer for Clinical Practice

Abstract

Preface. Introduction. 1: Genetic Predisposition and Illness: Introduction. 1.1. Genes and Environment. 1.2. Modes of Inheritance. 1.3. Autosomal Dominant Inheritance. 1.4. Studies at the DNA Level. 2: General Aspects of Colorectal Cancer: Introduction. 2.1. Incidence and Mortality. 2.2. The Role of Diet. 2.3. Tumour Localisation and Histological Types. 2.4. The Adenoma--Carcinoma Sequence. 2.5. Estimation of Risk for Colorectal Cancer. 2.6. Population Screening. 2.7. Groups at Increased Risk for Colorectal Cancer. 2.8. Intervention Studies. 3: Familial and Hereditary Colorectal Cancer: Introduction. 3.1. Family Studies of Patients with Colorectal Cancer. 3.2. Classification: Polyposis and Nonpolyposis Forms. 3.3. Hereditary Colorectal Cancer without Polyposis. 3.4. Hereditary Colorectal Cancer with Polyposis. 3.5. Intermediate and Miscellaneous Forms. 3.6. Risk Estimation for Family Members. 3.7. Screening of High-Risk Family Members. 3.8. Psychosocial Aspects of Familial Cancer. 4: Mechanisms of Colorectal Carcinogenesis: Introduction. 4.1. Chromosomal Abnormalities. 4.2. Oncogenes and Tumour Suppressor Genes. 4.3. DNA Repair and Immunological Mechanisms. 4.4. Proliferation Biomarkers. 4.5. Tumour Biomarkers. 5: Clinical Examples. 6: Guidelines for Clinical Practice. Bibliography. Index.