Abstract
Sydenham chorea (SC), a major manifestation of rheumatic fever (RF), is thought to occur when antibodies directed against group A streptococcus (GAS) cross-react with epitopes on neurons of the basal ganglia. In earlier work with SC, Swedo and colleagues identified children who, in addition to chorea, presented with obsessive-compulsive behavior. A precipitous onset of childhood obsessive-compulsive disorder (OCD) after streptococcal pharyngitis was subsequently described that shared many similarities to SC but did not have chorea or clinical signs of RF such as arthritis and carditis. Swedo and colleagues termed this subtype of childhood-onset OCD, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the American Academy of Child & Adolescent Psychiatry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
