Abstract

253Autism is a neuropsychiatric disorder that exhibits high heri-tability and is considered to have a complex genetic etiology. Asibling of a child with autism has a 25 to 50 times greater riskfor developing autism than someone in the general population.Autism displays both clinical and genetic heterogeneity, as reviewedin last month’s column. A different set of genes may confer riskin different families or individuals (genetic heterogeneity), anddifferent siblings in a given family may have a different clinical

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