Abstract
In the case of aneurysms, factors in the vessel wall, not least the ECM with specific proteins like collagen and elastin and proteoglycans as well as the cells themselves, are obvious candidates in pathogenesis. The role of elastase (and other proteases), neutrophil influx and complement in the weakening of the wall of the aorta, has been investigated in a series of elegant rodent models, including the impact of chronic as opposed to short-term cigarette smoke exposure. 11-14 A number of regions on chromosomes are increasingly implicated to contain sequences that appear to influence the development of arterial disease. These include
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