Abstract
Genetic factors explain a high proportion of the age-specific differences in bone density, size and turnover. The potential for interaction between hormonal, diet and lifestyle factors is likely to be important. Common allelic variation in the VDR is an example of normal gene variants altering Ca homoeostasis, with effects on body and bone size as well as bone density. The VDR findings suggesting interactions between genetic and nutritional factors are an important target for future research. These studies are complicated by the potential for effects of gene-gene interactions and of undefined environmental factors. These problems notwithstanding, considerations of environmental and nutritional contributions, such as Ca intake and vitamin D status, will be critical in interpreting these genetic pathways and in 'personalizing' nutritional recommendations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
