Genetically Engineered Cell Membrane Modified Conjugated Polymer Nanoparticles for NIR‐II Photothermal Therapy

Abstract

AbstractTumor‐selective near infrared‐induced photothermal therapy is a successful approach for ablation of malignant and cancerous cells. In the NIR region, tissue penetration depth in the near‐infrared second region (NIR‐II, 1000–1700 nm) is deeper than that of the traditional near‐infrared first region (NIR‐I, 700–900 nm) for the lower scattering and absorption. However, there are few photothermal conversion agents (PCAs) in the NIR‐II. And these PCAs are quickly identified by the immune system and rapidly cleared by the reticuloendothelial system (RES), leading to low accumulation in tumor, which prevents further advanced clinical practice. In this work, the conjugated polymer, PBTPBFTDPP, is prepared and assembled into nanoparticles (SPN). Then, the genetically engineered cell membranes are coated on the surface of SPN to obtain the positive targeting ability (SPN‐TF). The obtained SPN‐TF nanoparticles exhibit an excellent photothermal conversion ability, predominant targeting efficiency, and superb photothermal therapy for anticancer both in vitro and in vivo. These works will inspire more translational work on SPN for future clinical applications.