Abstract
CHD5 is an essential factor for neuronal differentiation and neurodegenerative diseases. Here, the targeted next generation sequencing and TaqMan genotyping technologies were carried out for CHD5 gene in a two-staged case-control study in Chinese population. The genetic statistics and gene-environment interactions were analyzed to find certain risk factors of Alzheimer's disease. We found intronic rs11121295 was associated with the risk of Alzheimer's disease at both stages including combined cohorts. This risk effect presented consistently significant associations with the alcoholic subgroups at both all stages in the stratified analysis. The gene-environment interactions further supported the above findings. Our study highlighted the potential role of CHD5 variants in conferring susceptibility to sporadic Alzheimer's disease, especially modified its risk by alcoholic intake.
Highlights
Alzheimer’s disease, a progressive neurodegenerative disorder, is one of the major dementia in elderly people that usually starts slowly and worsens over time [1]
Chromodomain helicase DNA-binding protein 5 (CHD5) is an essential factor for neuronal differentiation and neurodegenerative diseases
Our study highlighted the potential role of CHD5 variants in conferring susceptibility to sporadic Alzheimer’s disease, especially modified its risk by alcoholic intake
Summary
Alzheimer’s disease, a progressive neurodegenerative disorder, is one of the major dementia in elderly people that usually starts slowly and worsens over time [1]. It causes a tremendous societal challenge because the popularity of Alzheimer’s disease continues to rise. It affects about 6% of people over 65 years of age, and there are approximately 30 million people worldwide with Alzheimer’s disease [2]. About 70% of the risk is believed to be genetic with many genes usually involved [3]. Other risk factors include a history of head injuries, depression and anxiety, or hypertension
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