Genetic variations in bitter and sweet taste receptors in Taiwanese patients with chronic rhinosinusitis.

Abstract

Genetic variations of bitter and sweet taste receptors have been related to the pathophysiology of chronic rhinosinusitis (CRS). In this study, we attempted to explore the genetic variations of bitter and sweet taste receptors in Taiwanese CRS patients. Five hundred and sixty-six CRS patients and 5,660 control subjects were selected from participants in the Taiwan Precision Medicine Initiative. Amongst the 566 CRS patients, 186 were with nasal polyps (CRSwNP), while the other 380 were without (CRSsNP). Surgical specimens obtained from 292 CRS patients revealed that 177 were eosinophilic CRS, with the other 115 being non-eosinophilic CRS. There were 591,048 single nucleotide polymorphisms (SNPs) for analysis in all the eligible subjects, including 2 bitter taste receptor SNPs (rs713598, rs10246939) and 1 sweet taste receptor SNP (rs35874116). The minor allele frequencies (MAFs) of rs713598, rs10246939 and rs35874116 were 0.298, 0.297 and 0.078 for CRS patients and 0.306, 0.306 and 0.087 for the control subjects, were 0.301. 0.301 and 0.067 in CRSwNP patients, and 0.295, 0.295 and 0.084 in CRSsNP patients, and were 0.302, 0.302 and 0.085 in the eosinophilic CRS patients, and 0.283,0.287 and 0.087 in the non-eosinophilic CRS patients. The MAFs of rs713598, rs10246939 and rs35874116 were not significantly different between CRS patients and control subjects, between CRSwNP and CRSsNP patients, and between eosinophilic CRS and non-eosinophilic CRS patients. We did not find an association between three variants of the bitter taste receptor TAS2R38 and the sweet taste receptor TAS1R2 and Taiwanese CRS patients. This article is protected by copyright. All rights reserved.