Genetic variation within and between lines of diabetes-prone and non-diabetes-prone BB rats; allele distribution of 8 protein markers

Abstract

Twenty-four inbred and 2 outbred lines of the BB rat have been genetically characterized by establishing the allele distribution of 8 monogenic protein markers. The marker genes are: plasma alkaline phosphatase-1 (Alp-1), catalase-1 (Cs-1), carboxylesterases (Es-1, Es-2, Es-14), glyoxalase I (Glo-1), group specific component (Gc), and haemoglobin-beta-chain (Hbb). At least 3 linkage groups are represented by this set of markers. Genetic variation was found both within and between lines. Within-line variation was observed in 4 lines, including the 2 outbred lines. The other 22 lines could be subdivided into 4 groups, each representing a unique allele distribution pattern.