Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S Aulchenko,Dirk Goossens,Jenny Link,Ilse A Hoppenbrouwers,Rogier Q Hintzen,George C Ebers,Naghmeh Jafari,A Dessa Sadovnick,Cornelia M Van Duijn,Linda Broer,Wangko Lundström,Jurgen Del-Favero,Jan Hillert,Eva Greiner,Christine Van Broeckhoven,Ben A Oostra,Sreeram V Ramagopalan

doi:10.1038/ng.251

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S Aulchenko, Dirk Goossens + Show 15 more

https://doi.org/10.1038/ng.251

Copy DOI

Journal: Nature Genetics	Publication Date: Nov 9, 2008
Citations: 182

Affiliation: University of Antwerp, Karolinska Institutet, Erasmus University Rotterdam, Erasmus MC, Wellcome Centre for Human Genetics, University of Oxford, University of British Columbia

#KIF1B Gene #Multiple Sclerosis + Show 7 more

Abstract
Full-Text PDF
Similar Papers

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Full Text