Genetic variation in the insulin receptor substrate-1 gene in Asian Indians with obstructive sleep apnea and non alcoholic fatty liver disease

Abstract

with a physiologically relevant stimulus. Individual subjects spent two different nights in the lab, during which subjects performed timed trials before and after sleep on one of two unique but equally difficult computer-generated 3D spatial mazes. One night’s sleepwas normally consolidated with use of therapeutic CPAP throughout, while on the other night, CPAP was reduced only in REM sleep allowing REM OSA to recur. Results: REM disruption via this method caused reduction of REM sleep and significantly fragmented any remaining REM sleepwithout affecting total sleep time, sleep efficiency, or slow wave sleep. We observed improvements in maze completion time, distance traveled, and distance spent backtracking after a night of normal sleep that were significantly attenuated after a night of REM disruption without changes in psychomotor vigilance. Furthermore, the degree of improvement in maze completion time significantly positively correlated with the mean REM run duration across both sleep conditions. Conclusion: In conclusion, we demonstrate a novel role for REM sleep in human memory formation and highlight a significant cognitive consequence of OSA. Acknowledgements: This work was supported by the philanthropy of the James Kuhn Friends of SleepMedicine, the NYU CTSA grant UL1T38 from the National Center for the Advancement of Translational Science (NCATS), the American Sleep Medicine Foundation Physician Scientist Training Award, and by NHLBI K24 grant HL109156.