Abstract
There have been numerous genetic causes of obesity specifically leptin, genetic variants of the leptin receptor gene (LEPR Gln223Arg) which appeared to be polymorphismized (A>G; rs1137101) have been implicated in the pathogenesis of obesity in several populations, although no association has been evidenced in other regions in the world. In this study, the association between LEPR Gln223Arg polymorphism with Body Mass Index (BMI) and plasma leptin levels in obese diabetic and obese non-diabetic adults who are randomly selected from Erbil city is evaluated. Blood samples were collected for DNA extraction, and plasma leptin measurements. LEPR (A > G; rs1137101) genotypes were identified by a PCR- RFLP. The results show that plasma leptin concentrations increased with body mass index, and in obese diabetic group was more than two-fold increases p=0.001 when compared to those of obese non-diabetic patients. LEPR (A > G; rs1137101) gene polymorphisms did not found associated with BMI in the whole studied population. Furthermore an increased frequency of the GG genotype in the female control group 32.1 compared to obese group 19.2, but the frequency did not significant (OR= 1.38: 95% CI; 0.74-2.03, P=0.07 ) which indicated that this genotype might be associated with a protective effect against obesity in female only and that this effect was independent of diabetes. Further analysis of a larger population is required to confirm the biological relevance of this polymorphism for obesity in the Kurdish population.
Highlights
Since the LEPR Gln223Arg has a functional importance for obesity, it could play a significant role in type 2 diabetes mellitus and pathophysiology of human obesity [11]
In the Kurdistan regional of Iraq, few epidemiologic studies have been done to assess the prevalence of obesity and type II diabetes with the leptin receptor, it will be important to clarify the functionality of different genetic variants, since several studies have found significant associations linking them to several traits of obesity, diabetes or the metabolic syndrome [10]
The present study investigated the association between LEPR Gln 223 Arg (A > G; rs1137101) polymorphism in obese diabetic and obese non-diabetic subjects from Erbil city, and realize the possibility that the risk alleles for obesity involve in the increased risk of developing type 2 diabetes
Summary
( في افراد مصابين وغير مصابينLEPR Gln223Arg) التغايرات الجينية لجين مستقبل هرمون الليبتين بالسكري والذين يعانون السمنة في اربيل. Leptin receptors are present in the β-cell, it considered as an important regulator of pancreatic β-cell function at different levels including insulin secretion, insulin gene expression, cell growth, and apoptosis This hormone has a key function in the regulation of glucose homeostasis due to different levels of modulation of the pancreatic β-cell, it has been proposed that alterations in leptin signaling in the β-cell might be involved in diabetes in obese individuals [6,7]. Since the LEPR Gln223Arg has a functional importance for obesity, it could play a significant role in type 2 diabetes mellitus and pathophysiology of human obesity [11] They may share a common genetic background; that is, the risk alleles for obesity may be involved in the increased risk of developing type 2 diabetes [12]. The present study investigated the association between LEPR Gln 223 Arg (A > G; rs1137101) polymorphism in obese diabetic and obese non-diabetic subjects from Erbil city, and realize the possibility that the risk alleles for obesity involve in the increased risk of developing type 2 diabetes
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