Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

P Dongiovanni,G Marchesini,E Lattuada,E Mozzi,M A Zappa,M Maggioni,G Roviaro,V Nobili,J B S Leathart,C P Day,A L Fracanzani,R Rametta,A K Daly,L Valenti,A Pietrobattista,S Fargion,A D Burt

doi:10.1136/gut.2009.190801

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

P Dongiovanni, G Marchesini + Show 15 more

https://doi.org/10.1136/gut.2009.190801

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Journal: Gut	Publication Date: Feb 1, 2010
Citations: 182

Affiliation: University of Bologna, Istituti di Ricovero e Cura a Carattere Scientifico, Bambino Gesù Children's Hospital, Ospedale Maggiore, University of Milan

#Insulin Receptor Substrate-1 Polymorphisms #Liver Damage In Patients + Show 8 more

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Abstract

Background/aimsThe aim of this study was to assess the effect of functional ENPP1(ectoenzyme nucleotide pyrophosphate phosphodiesterase 1)/PC-1 (plasma cell antigen-1) and IRS-1 (insulin receptor substrate-1) polymorphisms influencing insulin receptor activity...

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