Abstract
Ovarian cancer is one of the common female malignant tumors globally. However, exactly mechanism of ovarian cancer remained unknown. HOTAIR, a lncRNA in the mammalian HOXC locus, has been fully explored for its genetic variants, expression level and carcinogenesis, development and progression of multiple cancers, except for ovarian cancer. In this study, we hypothesized that abnormal expression of HOTAIR and common variants of HOTAIR are associated with risk of Epithelial ovarian cancer (EOC). We first evaluated the HOTAIR levels in 100 paired tissues of EOC patients and corresponding normal tissues. Results showed that the expression level of HOTAIR in EOC tissues was significantly higher than that in corresponding normal tissues. Then the genotyping analyses of HOTAIR gene was conducted in a Chinese population. The results indicated that rs4759314 and rs7958904 were significantly associated with EOC susceptibility. For rs4759314, the difference between the G allele (as the reference) and the A allele was statistically significant (adjusted OR, 1.34; 95% CI: 1.08–1.65; P = 6.8 × 10−3). For rs7958904, C allele was associated a significantly decreased EOC risk when compared with G allele (OR: 0.77; 95% CI: 0.67–0.89; P = 4.2 × 10−4). The study identified that HOTAIR variants could be a useful biomarker for the predisposition to EOC and for the early diagnosis of the disease.
Highlights
Ovarian cancer is the most lethal gynecologic malignancy and the fifth cause of cancer-related deaths among females worldwide [1]
We hypothesized that abnormal expression of HOTAIR and common variants of HOTAIR are associated with risk of Epithelial ovarian cancer (EOC)
The results indicated that rs4759314 and rs7958904 were significantly associated with EOC susceptibility
Summary
Ovarian cancer is the most lethal gynecologic malignancy and the fifth cause of cancer-related deaths among females worldwide [1]. Epithelial ovarian cancer (EOC) accounts for 90% to 95% of all cases of ovarian cancer [2, 3]. HOTAIR, a lncRNA located in the HOXC locus, has been fully explored for its genetic variants, expression level and carcinogenesis, development and progression of multiple cancers [5,6,7,8,9,10,11,12]. Given the genetic variants and expression level of HOTAIR in carcinogenesis, development and progression of multiple cancers [13, 14], we hypothesized that common variants of HOTAIR are associated with risk of EOC. We performed genotyping analyses of HOTAIR gene in this study conducted in Chinese population
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