Abstract
BackgroundThe human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. Further, AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished in brain regions potentially involved in the regulation of eating behavior in rats which are more sensitive to cocaine and alcohol. We hypothesized that the human AKR1B10 gene may also play a role in the regulation of human eating behavior.ResultsWe investigated the effects of 5 genetic variants of AKR1B10 on human eating behavior among 548 subjects from a German self-contained population, the Sorbs, and in 350 subjects from another independent German cohort. Among the Sorbs, we observed nominal associations with disinhibition at the 5′ untranslated region (5′ UTR) variant rs10232478 and the intragenic variants rs1834150 and rs782881 (all P ≤ 0.05). Further, we detected a relationship of rs1834150 and rs782881 with waist, smoking consumption (rs782881) and coffee consumption (rs1834150) (all P ≤ 0.05). Albeit non-significant, replication analyses revealed similar effect directions for disinhibition at rs1834150 (combined P = 0.0096). Moreover, in the replication cohort we found rs1834150 related to increased restraint scores with a similar direction as in the Sorbs (combined P = 0.0072).ConclusionOur data suggest that genetic variants in the AKR1B10 locus may influence human eating behavior.Electronic supplementary materialThe online version of this article (doi:10.1186/s12863-015-0189-9) contains supplementary material, which is available to authorized users.
Highlights
The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion
Diabetes was diagnosed based on a 75 g oral glucose tolerance test (OGTT) and the definition of type 2 diabetes (T2D) according to ADA criteria [33]
Association analysis in sorbs We observed nominally significant associations with disinhibition at the variant rs10232478 located in the 5′ untranslated region and the intronic Single nucleotide polymorphisms (SNP) rs1834150 and rs782881 (Table 2)
Summary
The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished in brain regions potentially involved in the regulation of eating behavior in rats which are more sensitive to cocaine and alcohol. We hypothesized that the human AKR1B10 gene may play a role in the regulation of human eating behavior. The NADP(H)-dependent (nicotinamide adenine dinucleotide phosphate) enzyme is mostly expressed in the gastrointestinal tract, in the small intestine, and colon as well as adrenal gland [1,2]. It reduces a wide spectrum of natural or synthetic harmful components present in daily nutrients and may be involved in detoxification mechanisms [3].
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