Abstract
Outcomes from extinction therapy for anxiety ( Biol Psychiatry 2009; 66:636) have been associated with a polymorphism at codon 66 of the gene for brain-derived neurotrophic factor (BDNF) that leads to a valine (Val) to methionine (Met) substitution (Val66Met). In mice, presence of the Met allele was associated with slower extinction of fear, which was rescued by d-cycloserine. d-cycloserine, which acts at the …
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