Abstract
This paper summarizes the results of a study of human breast cancers performed mainly at the Centre René Huguenin in collaboration with other American and French groups, and supported in part by a Grant from the Association pour la Recherche sur le Cancer (ARC) Villejuif 1∗. During this work, the following conclusions emerged: • c- myc proto-oncogene amplification is a common alteration in ductal invasive tumors, more frequently found in recurrent and metastatic tumors, suggesting a role for c- myc in tumor progression. However, in the current state of our study, it does not appear to be linked to prognosis; • parts of the short arm of chromosome 11 are deleted in 20% of tumors resulting in hemizygosity for several genes (c-ha- ras, β globin, pTH, calcitonin, catalase). These deletions seem to be linked with aggressiveness of tumors; • a restriction fragment length polymorphism (RFLP) study of c-ha- ras has shown a significant association of the frequency of rate ha- ras alleles in cancer patients compared to that of normal individuals. Although this result is currently a matter of controversy, further studies must be independently repeated to be conclusive; • another RFLP was found in c- mos proto-oncogene, which is detected only in patients with breast cancers or other types of tumors. The molecular basis for this RFLP has been elucidated. The significance of this association is unknown.
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