Abstract
In many countries of the world despite the extensively vaccination against pertussis has increased the incidence of the whooping cough in all age group of the population. The MLST, MLVA and CGH investigations revealed the differences in genotypes between the vaccine strains B.pertussis and the circulating isolates B.pertussis in consequence of adaptation of the bacterium B.pertussis to the immunized hosts. It is lead to waning immynity and outbreak of incidence of pertussis. The mutations in the genes encoding the major virulence factors, the allelic polimorfism and decreasing the genome size of B.pertussis strains are the basis of the B.pertussis adaptation to the immunized hosts and dependent on the type of the vaccine used for immunization Programme. In countries that use acellular pertussis vaccine for vaccination programme the dominant isolates genotypes are: ptxА1-ptxС2- ptxР3-prn2- tcfA2-1-fim3-2 и ptxА1- ptxС2- ptxР3-prnА2- tcfA2- fim2-1- fim3-1, and that use the cellular pertussis vaccine the dominant isolates genotypes are ptxА1-ptxС1- ptxР1-prn1- tcfA2- fim2-2 fim3-1 и ptxА1- ptxС1- ptxР1- prn2- tcfA2- fim2-1- fim3-1. The constant monitoring of the genotypes of isolates B.pertussis is necessary to reveal the dominant genotypes and include them in the national immunization programme in combination with vaccine strains B.pertussis.
Highlights
In many countries of the world despite the extensively vaccination against pertussis has increased the incidence of the whooping cough in all age group of the population
The Multi-Locus Seqvence Typing (MLST), Multi-Locus Variable Number of Tandem Repeat Analysis (MLVA) and Comparative Genomic Hybridization (CGH) investigations revealed the differences in genotypes between the vaccine strains B.pertussis and the circulating isolates B.pertussis in consequence of adaptation of the bacterium B.pertussis to the immunized hosts
The mutations in the genes encoding the major virulence factors, the allelic polimorfism and decreasing the genome size of B.pertussis strains are the basis of the B.pertussis adaptation to the immunized hosts and dependent on the type of the vaccine used for immunization Programme
Summary
In many countries of the world despite the extensively vaccination against pertussis has increased the incidence of the whooping cough in all age group of the population. MLST, MLVA и CGH исследования выявили несоответствие генотипов циркулирующих штаммов B.pertussis генотипам вакцинных штаммов, вследствие адаптации бактерий к вакцинированному хозяину, что привело к снижению иммунитета и возникновению вспышек заболевания коклюшем. Кодирующих основные факторы вирулентности, аллельный полиморфизм, редукция генома в циркулирующих штаммах B.pertussis как основа адаптации патогена к условиям вакцинации популяции. Анализ B.pertussis штаммов из различных Европейских стран выявил отсутствие RD10 в ptxP3 штаммах.
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