Abstract
Abstract The epidemic of HIV-1 CRF01_AE has become one of major public health issues in China. We sought to characterize the transmission patterns of networks for this strain nationwide and elucidate possible opportunities for prevention. All available CRF01_AE pol sequences (n = 4, 704) from China in the HIV LANL were isolated and conducted genetic transmission network analysis. A total of 1, 391 (29.6%) sequences were identified as belonging to 400 separate networks. Of men who have sex with men (MSM) in networks, 93.8% were linked to other MSM and only 2.4% were linked to heterosexual women. However, 11.8% heterosexual women in networks were linked to MSM. The lineages mainly composed of MSM had a higher transmission than those major consisted of heterosexuals. Of the 1, 391 individuals in networks, 36.9% (513) were linked to cases diagnosed in different provinces. The proportions of individuals involved in inter-province links by province was interrelated with the number of migrant people (Spearman r =0.738, P =0.001). This study could help improve our ability to understand HIV transmission among various regions and risk groups in China, and highlighted the importance of targeting MSM and migrants by prevention and intervention efforts.
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