Genetic Susceptibility to Ketosis in Cattle: Current State of Research

Abstract

High-yield productivity in dairy cows is due to intense functioning of all organs and organism systems, that predisposes animals to various forms of disorders of metabolic processes. Progress of energy disbalance in high-yield dairy cows during lactation contributes to the development of systemic metabolic disorders, negatively affecting milk production and reproductive potential of animals. Interest in breeding ketosis resistant cattle is global and finding of mutations, gene variants and molecular and genetic processes contributing to one or another phenotype are considered as key steps in understanding a degree of susceptibility to ketosis. These steps will also give an insight in etiology of ketosis and provide basis for designing novel effective breeding programs. In this paper we present an overview of studies based on genetic and molecular research methods in finding genetic markers of cattle ketosis development. We discuss comprehensive SNPs localization of GWAS meta-analysis data, protein-protein interactions of associated with SNPs candidate genes via STRING, as well as SNPs annotation of associated biological processes. We provide candidate gene expression profiles for associated with ketosis tissues based on human data with GTEx tool.