Abstract
ObjectiveGenetic factor plays an important role in early failure of total hip arthroplasty (aseptic loosening) etiology, and TIMP-1 gene may be involved. The present study was conducted to reveal possible association between TIMP-1 polymorphisms with the risk of early failure of total hip arthroplasty (THA) (aseptic loosening).MethodsThe TIMP-1 single nucleotide polymorphisms (SNPs) rs4898, rs6609533, and rs2070584 were genotyped in 59 subjects who were diagnosed as aseptic loosening after total hip arthroplasty and in 100 controls.ResultsThe TIMP-1 SNP rs4898 T allele in the case group was found to be 1.32 fold (P = 0.0013, 95% CI = 1.16 to 1.58) than the control group. Similarly, the G allele of rs6609533 was found to be associated with increased risk of aseptic loosening (OR = 1.78, 95% CI = 1.52 to 2.17, P < 0.0001). For SNP rs2070584, no statistical association was found (A vs. G, OR = 1.14, 95% CI = 0.97 to 1.40, P = 0.2028).ConclusionThe results showed that the TIMP-1 SNPs rs4898 and rs6609533 were associated with the increased risk of early aseptic loosening susceptibility.
Highlights
There are numerous patients with end stage arthritis treated with cemented total hip arthroplasty (THA), and the number is rapidly increasing [1,2,3,4]
This study aims to determine whether the tissue inhibitors of metalloproteinases (TIMPs)-1 single nucleotide polymorphisms (SNPs) rs4898, rs6609533, and rs2070584 were associated with failure of THA in Chinese Han population
Association of TIMP-1 polymorphisms with susceptibility to failure of THA As expected, the distribution of the genotypes of SNPs of TIMP-1 gene conformed to the Hardy–Weinberg equilibrium and the genotyping success rate was 100%
Summary
Association of TIMP-1 polymorphisms with susceptibility to failure of THA As expected, the distribution of the genotypes of SNPs of TIMP-1 gene conformed to the Hardy–Weinberg equilibrium and the genotyping success rate was 100%. The TIMP-1 SNPs rs4898 and rs6609533 were found to be significantly associated with an increased risk of THA failure after adjustment of age, gender, and BMI. The TIMP-1 SNP rs4898 T allele in the case group was found to be 1.32 fold (P = 0.0013, 95% CI = 1.16 to 1.58) than the control group. The G allele of rs6609533 was found to be associated with an increased risk of aseptic loosening (OR = 1.78, 95% CI = 1.52 to 2.17, P < 0.0001). The LD within TIMP-1 gene was only found between rs4898 and rs6609533, showing that these two polymorphisms belong to one haploblock (Figure 1)
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