Genetic Studies of a STR at the vWF Locus and Its Application to Individualisation

Abstract

The feasibility of DNA analysis from minute and even partially degraded samples, may explain in some extent the increasing interest in PCR technology in the characterization from human biological remains [1,2]. The introduction of the STR (“Short Tandem Repeats”) [3,4] is substantially enlarging the battery of possible DNA markers susceptible to application in these types of studies with this finality. This work concerns preliminary formal and population genetic studies on a tetranucleotide repeat in the intron 40 (between nt 1640–1750) in the von Willebrand Factor locus, vWF [5]. Further analyses in human biological remains are carried out with the objective of evaluating the usefulness of this STR in genetic individual profiling.KeywordsShort Tandem RepeatTetranucleotide RepeatDegraded SampleAllelic LadderUnrelated Healthy IndividualThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.