Abstract
Background: The chromosomal location of several genes for familial psoriasis has recently been reported. Objective: This article reviews these recent reports of genetic linkages in psoriasis. Methods: An explanation and discussion of the type of family material studied and the statistical approaches used are presented. Results: Linkage of psoriasis-susceptibility loci have been reported on chromosomes 17, 4, and 6. Conclusion: Due to genetic heterogeneity and decreased penetrance, confirmation of reported genetic linkages is likely to be difficult. The use of single, large families in which many members are affected with psoriasis may yield the most information.
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