Abstract
Background The nitric oxide (NO) receptor soluble guanylyl cyclase (sGC) is composed of two subunits of a1,2 and b1,2, sGCa1b1 being the major heterodimer that catalyzes the formation of second messenger cGMP. NO-cGMP signaling plays a critical role in numerous processes, and retarded signaling function by either limited NO bioavailability, or decrease in expression or activity of sGC correlates with several disease states including hypertension, neurodegenerative disorders, inflammation, and cancer. Our analysis of human databases revealed a statistically significant reduction of sGC transcript levels in multiple human cancer specimens including glioma and breast cancers. We have recently demonstrated that restoration of sGC expression levels in glioma cell lines significantly reduced cell proliferation, colony formation, and growth of orthotopically implanted glioma cells in mice, suggesting a potent anti-tumor property for the sGC. However, the mechanism underlying the genetic silencing of sGC in cancer is unknown.
Highlights
The nitric oxide (NO) receptor soluble guanylyl cyclase is composed of two subunits of a1,2 and b1,2, sGCa1b1 being the major heterodimer that catalyzes the formation of second messenger cGMP
We have recently demonstrated that restoration of sGC expression levels in glioma cell lines significantly reduced cell proliferation, colony formation, and growth of orthotopically implanted glioma cells in mice, suggesting a potent anti-tumor property for the sGC
Here we report that sGCb1 is regulated epigenetically by histone acetylation in breast and lung cancers cell lines
Summary
The nitric oxide (NO) receptor soluble guanylyl cyclase (sGC) is composed of two subunits of a1,2 and b1,2, sGCa1b1 being the major heterodimer that catalyzes the formation of second messenger cGMP. Genetic silencing of sGC b1 in cancer: role of epigenetic regulation From 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications Erfurt, Germany. Background The nitric oxide (NO) receptor soluble guanylyl cyclase (sGC) is composed of two subunits of a1,2 and b1,2, sGCa1b1 being the major heterodimer that catalyzes the formation of second messenger cGMP.
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