Abstract
Although II-TES mice release large amounts of murine mammary tumor virus (MMTV) in milk, they are resistant to mammary tumorigenesis. High mammary tumor incidence was observed in ( BALB ca × II-TES)F1 and ( C57BL 6N × II-TES)F1 , whereas no mammary tumors developed in BALB ca × OZ-F)F1 . Mammary tumors developed in 68% of (OZ-F × (OZ-F × II-TES)F1) and 45% of (II-TES × (OZ-F × II-TES)F1). These results suggest that the II-TES mouse carries a recessive gene for mammary tumor resistance which does not inhibit MMTV release, and two independent dominant mammary tumor promoting genes which are inhibited by the resistant gene.
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