Abstract
Between February and April 2018, three ceftriaxone-resistant and high-level azithromycin-resistant Neisseria gonorrhoeae cases were identified; one in the United Kingdom and two in Australia. Whole genome sequencing was used to show that the isolates from these cases belong to a single gonococcal clone, which we name the A2543 clone.
Highlights
Between February and April 2018, three ceftriaxone-resistant and high-level azithromycin-resistant Neisseria gonorrhoeae cases were identified; one in the United Kingdom and two in Australia
Isolates from the three cases exhibited both resistance to ceftriaxone (0.25–0.5 mg/L) and high-level resistance to azithromycin according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) resistance breakpoints, requiring the patients to undergo extensive follow-up and treatments including days of hospitalisation and intravenous therapies [1,2]
The first three ceftriaxone-resistant, high-level azithromycin resistant Neisseria gonorrhoeae (NG) isolates seen worldwide were isolated within a two-month period of each other (February–April 2018)
Summary
Genetic relatedness of ceftriaxone-resistant and highlevel azithromycin resistant Neisseria gonorrhoeae cases, United Kingdom and Australia, February to April 2018. Citation style for this article: Jennison Amy V, Whiley David, Lahra Monica M, Graham Rikki M, Cole Michelle J, Hughes Gwenda, Fifer Helen, Andersson Monique, Edwards Anne, Eyre David, http. Between February and April 2018, three ceftriaxone-resistant and high-level azithromycin-resistant Neisseria gonorrhoeae cases were identified; one in the United Kingdom and two in Australia. Between February and April 2018, Neisseria gonorrhoeae (NG) isolates displaying ceftriaxone resistance and high-level azithromycin resistance were independently reported from both the United Kingdom (UK) (one case) and Australia (two cases) [1,2]. This study has demonstrated that a single XDR clone, with epidemiological links to Asia, has been successfully transmitted on least three independent occasions and may be still circulating, which is of global public health significance
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