Abstract
Aspergillus nidulans is a multicellular fungus whose genetic system can be manipulated with exceptional ease and sophistication. Development of conidiophores, the asexual reproductive structures formed by A. nidulans, is characterized by major qualitative changes in gene transcription. Elucidation of the molecular mechanisms through which conidiation-specific gene products control and execute the orderly elaboration of the conidiophore is facilitated by the ability to clone developmentally regulated genes, to alter them in vitro, and then to reintroduce them into the organisms's genome with precision. Application of this molecular genetic approach has led to new insights into the chromosomal organizations, biological functions and regulated expression of genes that are specifically activated during A. nidulans development.
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