Abstract
A recombinant that has the transforming activity of a Rous sarcoma virus (helper-independent) and the subgroup specificity of an avian leukosis virus has been isolated from cells infected with these two types of virus. The temperature sensitivity of a sarcoma virus mutant was unaffected following alteration of the host range by recombination. The high frequency of recombination observed seems to support the assumption that the virus genome is composed of several subunits. On the other hand, the helper-independent nature of the Bryan strain of Rous sarcoma virus was not altered following replication with leukosis virus. The recombination may be restricted in this strain, or it may be insufficient to restore the defective function of the virus. Nontransforming viruses were found in all preparations of genetically purified transforming recombinants, suggesting that the loss of the gene(s) related to cell transformation is not a rare event.
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