Genetic profiling characteristics of patients with low-grade serous carcinoma of the ovary in a racially diverse population

Abstract

Objective: Low-grade serous ovarian carcinoma (LGSOC) commonly carries mutations in the MAP kinase pathway (KRAS, NRAS, BRAF). Penetrance of mutations in this pathway is reported to be approximately 50%. The role of other mutations in the pathogenesis of this disease is poorly understood. Our objective was to evaluate the penetrance of pathogenic mutations outside of this pathway in a racially diverse population.