Abstract
The current study analyses the frequency of the positive family history and cancer predisposition syndromes in large cohort of patients with sympathetic nervous system tumors treated in Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev. Positive family history and cancer predisposition genetic syndromes were observed in 0.5% and 1.5% cases of neuroblastoma, consequently. The article contains the review of the current literature devoted to mechanisms of genetic predisposition to neuroblastoma including cancer predisposition syndromes and genetics of sporadic cases.
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